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Applied cometrics (AAPS Advances in the ceutical Sciences Series (14))

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This comprehensive volume provides an update on the current state of cometrics in drug development. It consists of nineteen chapters all written by leading scientists from the ceutical industry, regulatory agencies and academia. After an introduction of the basic cokinetic and codynamic concepts of cometrics in drug development, the book presents numerous examples of specific applications that utilize cometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, es, obesity, infections, psychiatrics, Alzheimer’s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying cometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, cometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, cometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.

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